Combined Oral Administration of GABA and DPP-4 Inhibitor Prevents Beta Cell Damage and Promotes Beta Cell Regeneration in Mice

γ-aminobutyric acid (GABA) or glucagon-like peptide-1 based drugs, such as sitagliptin (a dipeptidyl peptidase-4 inhibitor), were shown to induce beta cell regenerative effects in various diabetic mouse models. We propose that their combined administration can bring forth an additive therapeutic eff...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Wenjuan, Son, Dong Ok, Lau, Harry K., Zhou, Yinghui, Prud’homme, Gerald J., Jin, Tianru, Wang, Qinghua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476705/
https://ncbi.nlm.nih.gov/pubmed/28676760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00362
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