Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice

Glucagon-like peptide-1 (GLP-1), an incretin hormone plays an important role in regulating glucose homeostasis. The therapeutic use of native GLP-1 is inadequate due to its short in vivo half-life. We recently developed a novel GLP-1 mimetics supaglutide, and demonstrated that this formulation retai...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Ren, Liwei, Cui, Qiaoli, Liu, Wenjuan, Wang, Liqian, Liao, Yijing, Feng, Ying, Sun, Wanwan, Yang, Yehong, Zhang, Zhaoyun, Jin, Tianru, Prud’homme, Gerald J., Zhang, Lina, Li, Yiming, Leng, Ying, Wang, Qinghua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6670290/
https://ncbi.nlm.nih.gov/pubmed/31404283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2019.00930
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