Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways

Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunisti...

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Bibliografski detalji
Izdano u:Front Cell Infect Microbiol
Glavni autori: Rodríguez-Arce, Irene, Martí, Sara, Euba, Begoña, Fernández-Calvet, Ariadna, Moleres, Javier, López-López, Nahikari, Barberán, Montserrat, Ramos-Vivas, José, Tubau, Fe, Losa, Carmen, Ardanuy, Carmen, Leiva, José, Yuste, José E., Garmendia, Junkal
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Microbiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476696/
https://ncbi.nlm.nih.gov/pubmed/28676846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00266
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