Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways

Antibacterial treatment with cotrimoxazol (TxS), a combination of trimethoprim and sulfamethoxazole, generates resistance by, among others, acquisition of thymidine auxotrophy associated with mutations in the thymidylate synthase gene thyA, which can modify the biology of infection. The opportunisti...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Rodríguez-Arce, Irene, Martí, Sara, Euba, Begoña, Fernández-Calvet, Ariadna, Moleres, Javier, López-López, Nahikari, Barberán, Montserrat, Ramos-Vivas, José, Tubau, Fe, Losa, Carmen, Ardanuy, Carmen, Leiva, José, Yuste, José E., Garmendia, Junkal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476696/
https://ncbi.nlm.nih.gov/pubmed/28676846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2017.00266
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