APPswe/PS1dE9 mice with cortical amyloid pathology show a reduced NAA/Cr ratio without apparent brain atrophy: A MRS and MRI study

Transgenic animal models of Aβ pathology provide mechanistic insight into some aspects of Alzheimer disease (AD) pathology related to Aβ accumulation. Quantitative neuroimaging is a possible aid to improve translation of mechanistic findings in transgenic models to human end phenotypes of brain morp...

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Detalhes bibliográficos
Publicado no:Neuroimage Clin
Main Authors: Kuhla, Angela, Rühlmann, Claire, Lindner, Tobias, Polei, Stefan, Hadlich, Stefan, Krause, Bernd J., Vollmar, Brigitte, Teipel, Stefan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476467/
https://ncbi.nlm.nih.gov/pubmed/28652970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nicl.2017.06.009
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