Zika virus produces non-coding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease

The outbreak of Zika virus (ZIKV) and associated fetal microcephaly mandates efforts to understand the molecular processes of infection. Related flaviviruses produce non-coding subgenomic flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice. These viruses make sfRNAs by co-opting...

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Pubblicato in:Science
Autori principali: Akiyama, Benjamin M., Laurence, Hannah M., Massey, Aaron R., Costantino, David A., Xie, Xuping, Yang, Yujiao, Shi, Pei-Yong, Nix, Jay C., Beckham, J. David, Kieft, Jeffrey S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476369/
https://ncbi.nlm.nih.gov/pubmed/27934765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aah3963
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