Computational explanation for bioactivation mechanism of targeted anticancer agents mediated by cytochrome P450s: A case of Erlotinib

EGFR inhibitors, even with therapeutics superiorities in anticancer, can cause idiosyncratic pulmonary and hepatic toxicities that are associated with the reactive electrophile bioactivated by Cytochrome P450s (P450s). Until now, neither has the electrophilic intermediate been caught experimentally,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ai, Chun-Zhi, Liu, Yong, Li, Wei, Chen, De-Meng, Zhu, Xin-Xing, Yan, Ya-Wei, Chen, Du-Chu, Jiang, Yi-Zhou
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476264/
https://ncbi.nlm.nih.gov/pubmed/28628631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0179333
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