The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

The functional relationship between bile acid (BA) and autophagy has not been evaluated in the context of pancreatitis. Here we investigated whether BA and their nuclear farnesoid X receptor (FXR) modulate autophagy and the development of pancreatitis. FXR expression, autophagy, apoptosis and necrop...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Zhou, Xiaodong, Xie, Li, Bergmann, Frank, Endris, Volker, Strobel, Oliver, Büchler, Markus W, Kroemer, Guido, Hackert, Thilo, Fortunato, Franco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475417/
https://ncbi.nlm.nih.gov/pubmed/28660075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.27
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