The bile acid receptor FXR attenuates acinar cell autophagy in chronic pancreatitis

The functional relationship between bile acid (BA) and autophagy has not been evaluated in the context of pancreatitis. Here we investigated whether BA and their nuclear farnesoid X receptor (FXR) modulate autophagy and the development of pancreatitis. FXR expression, autophagy, apoptosis and necrop...

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Publicat a:Cell Death Discov
Autors principals: Zhou, Xiaodong, Xie, Li, Bergmann, Frank, Endris, Volker, Strobel, Oliver, Büchler, Markus W, Kroemer, Guido, Hackert, Thilo, Fortunato, Franco
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475417/
https://ncbi.nlm.nih.gov/pubmed/28660075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2017.27
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