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TMOD-02. PEDIATRIC MEDULLOBLASTOMA XENOGRAFT GROWTH LOCATION TRANSFORMS TRANSCRIPTOMIC BUT NOT PHENOTYPIC PROFILES AND ALTERS SENSITIVITY TO RADIATION

Patient-derived xenograft models maintained in immunodeficient mice provide a powerful preclinical tool for testing oncologic therapies. Xenograft response to treatment informs which agents advance to human clinical trials. Frequently, pediatric brain tumor models are grown and tested heterotopicall...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Etminan, Tina, Nan, Li, Moore, Blake, Orr, Brent, Hjelmeland, Anita, Ring, Eric, Beierle, Elizabeth, Markert, James, Chewning, Joseph, Crossman, David, Gillespie, Yancey, Friedman, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475177/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.202
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