LGG-08. A PHASE II PROSPECTIVE STUDY OF SELUMETINIB IN CHILDREN WITH RECURRENT OR REFRACTORY LOW-GRADE GLIOMA (LGG): A PEDIATRIC BRAIN TUMOR CONSORTIUM (PBTC) STUDY

A greater understanding of the Ras-MAP kinase-signaling pathway in pediatric low-grade glioma (LGG) has led to the ability to target this pathway with therapeutic intent. The PBTC conducted a multi-institutional phase II study (NCT01089101) evaluating selumetinib (AZD6244, ARRY-142886), a MEK I/II i...

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Publicado no:Neuro Oncol
Main Authors: Fangusaro, Jason, Onar-Thomas, Arzu, Poussaint, Tina Y, Wu, Shengjie, Ligon, Azra H, Lindeman, Neal, Banerjee, Anu, Packer, Roger J, Kilburn, Lindsay B, Pollack, Ian F, Jakacki, Regina I, Qaddoumi, Ibrahim, Fisher, Paul G, Dhall, Girish, Baxter, Patricia, Kreissman, Susan G, Stewart, Clinton F, Pfister, Stefan M, Jones, David TW, Vezina, Gilbert, Stern, Jessica, Panigrahy, Ashok, Jones, Blaise V, Patay, Zoltan, Tamrazi, Benita, Jones, Jeremy Y, Haque, Sofia S, Enterline, David S, Cha, Soonmee, Doyle, Laurence A, Smith, Malcolm, Boyett, James M, Dunkel, Ira J, Fouladi, Maryam
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475130/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.141
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