EPND-05. LYSINE SPECIFIC DEMETHYLASE-1 (LSD-1) INHIBITOR SYC-836 IN COMBINATION WITH RADIATION PROLONGS ANIMAL SURVIVAL IN PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MODEL OF POSTERIOR FOSSA EPENDYMOMA

BACKGROUND: Recent molecular subgrouping of ependymoma (EPN) has identified one group, posterior fossa A (PFA), to have one of the worst prognosis and driven by epigenetic changes, suggesting targeting epigenetic changes in PFA EPN can potentially be effective. In this study, we examined the therape...

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Vydáno v:Neuro Oncol
Hlavní autoři: Zhao, Sibo, Zhang, Huiyuan, Qi, Lin, Lindsay, Holly, Du, Yuchen, Kogiso, Mari, Braun, Frank, Injac, Sarah, Perlaky, Lazlo, Parsons, Donald W., Chintagumpala, Murali, Adesina, Adekunle, Song, Yongcheng, Li, Xiao-Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5475027/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.063
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