Hypoxia Response Element-Regulated MMP-9 Promotes Neurological Recovery via Glial Scar Degradation and Angiogenesis in Delayed Stroke

Matrix metalloproteinase 9 (MMP-9) plays a beneficial role in the delayed phase of middle cerebral artery occlusion (MCAO). However, the mechanism is obscure. Here, we constructed hypoxia response element (HRE)-regulated MMP-9 to explore its effect on glial scars and neurogenesis in delayed ischemic...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Cai, Hongxia, Ma, Yuanyuan, Jiang, Lu, Mu, Zhihao, Jiang, Zhen, Chen, Xiaoyan, Wang, Yongting, Yang, Guo-Yuan, Zhang, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474960/
https://ncbi.nlm.nih.gov/pubmed/28396199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.03.020
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