Genetic and small molecule disruption of the AID/RAD51 axis similarly protect NOD mice from type 1 diabetes through expansion of regulatory B-lymphocytes(,)

B-lymphocytes play a key role in type 1 diabetes (T1D) development by serving as a subset of APC preferentially supporting expansion of autoreactive pathogenic T-cells. As a result of their pathogenic importance, B-lymphocyte-targeted therapies have received considerable interest as potential T1D in...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Ratiu, Jeremy J, Racine, Jeremy J, Hasham, Muneer G, Wang, Qiming, Branca, Jane A, Chapman, Harold D, Zhu, Jing, Donghia, Nina, Philip, Vivek, Schott, William H, Wasserfall, Clive, Atkinson, Mark A, Mills, Kevin D, Leeth, Caroline M, Serreze, David V
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474749/
https://ncbi.nlm.nih.gov/pubmed/28461573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700024
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