Concise Whole-Cell Modeling of BK(Ca)-CaV Activity Controlled by Local Coupling and Stoichiometry

Large-conductance Ca(2+)-dependent K(+) (BK(Ca)) channels are important regulators of electrical activity. These channels colocalize and form ion channel complexes with voltage-dependent Ca(2+) (CaV) channels. Recent stochastic simulations of the BK(Ca)-CaV complex with 1:1 stoichiometry have given...

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Vydáno v:Biophys J
Hlavní autoři: Montefusco, Francesco, Tagliavini, Alessia, Ferrante, Marco, Pedersen, Morten Gram
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Cell Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474739/
https://ncbi.nlm.nih.gov/pubmed/28591611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.04.035
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