Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis

Reduced pancreatic islet levels of Munc18a/SNARE complex proteins have been postulated to contribute to the deficient glucose-stimulated insulin secretion (GSIS) in type-2 diabetes (T2D). Whereas much previous work has purported Munc18a/SNARE complex (Syntaxin-1A/VAMP-2/SNAP25) to be primarily invol...

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Vydáno v:EBioMedicine
Hlavní autoři: Qin, Tairan, Liang, Tao, Zhu, Dan, Kang, Youhou, Xie, Li, Dolai, Subhankar, Sugita, Shuzo, Takahashi, Noriko, Ostenson, Claes-Goran, Banks, Kate, Gaisano, Herbert Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474508/
https://ncbi.nlm.nih.gov/pubmed/28163042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.01.030
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