Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

Protein tyrosine phosphatase 1B (PTP1B) regulates leptin signaling in hypothalamic neurons via the JAK2-STAT3 pathway. PTP1B has also been implicated in the regulation of inflammation in the periphery. However, the role of PTP1B in hypothalamic inflammation, which is induced by a high-fat diet (HFD)...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Tsunekawa, Taku, Banno, Ryoichi, Mizoguchi, Akira, Sugiyama, Mariko, Tominaga, Takashi, Onoue, Takeshi, Hagiwara, Daisuke, Ito, Yoshihiro, Iwama, Shintaro, Goto, Motomitsu, Suga, Hidetaka, Sugimura, Yoshihisa, Arima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474442/
https://ncbi.nlm.nih.gov/pubmed/28094236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.01.007
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