CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1 Dependent Type I Interferon Response

Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of STAT1, induction of STAT1 regulated genes, and this process is inhibited by active caspases. STAT1 is enriched in CSCs in cancer cell lines, patient-derived human breast cancer, and...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Qadir, Abdul S., Ceppi, Paolo, Brockway, Sonia, Law, Calvin, Mu, Liang, Khodarev, Nikolai N., Kim, Jung, Zhao, Jonathan C., Putzbach, William, Murmann, Andrea E., Chen, Zhuo, Chen, Wenjing, Liu, Xia, Salomon, Arthur R., Liu, Huiping, Weichselbaum, Ralph R., Yu, Jindan, Peter, Marcus E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474321/
https://ncbi.nlm.nih.gov/pubmed/28273453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.037
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