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Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
Pharmacological levels of ascorbate have long been suggested as a potential treatment of cancer. However, we observed that EC50 of ascorbate was at a similar level for cultured healthy melanocytes and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer. Loss of 5-hydro...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473908/ https://ncbi.nlm.nih.gov/pubmed/28623268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03893-5 |
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