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Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
Pharmacological levels of ascorbate have long been suggested as a potential treatment of cancer. However, we observed that EC50 of ascorbate was at a similar level for cultured healthy melanocytes and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer. Loss of 5-hydro...
Guardat en:
| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473908/ https://ncbi.nlm.nih.gov/pubmed/28623268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03893-5 |
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