Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids

We employed a recently introduced class of sterol-modified lipids (SML) to produce m-PEG-DSPE containing liposome compositions with a range of cis-platinum content release rates. SML have a cholesterol succinate attached to the phosphatidylglycerol head group and a fatty acid at the 2 position. Thes...

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Bibliographic Details
Published in:	Eur J Pharm Sci
Main Authors:	Kieler-Ferguson, Heidi M., Chan, Darren, Sockolosky, Jonathan, Finney, Lydia, Maxey, Evan, Vogt, Stefan, Szoka, Francis C.
Format:	Artigo
Language:	Inglês
Published:	2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5473525/ https://ncbi.nlm.nih.gov/pubmed/28263913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2017.03.003
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Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids

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