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Loss of Navβ4-mediated regulation of sodium currents in adult Purkinje neurons disrupts firing and impairs motor coordination and balance
The resurgent component of voltage-gated Na(+) (Nav) currents, I(NaR), has been suggested to provide the depolarizing drive for high frequency firing and to be generated by voltage-dependent Nav channel block (at depolarized potentials) and unblock (at hyperpolarized potentials) by the accessory Nav...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473293/ https://ncbi.nlm.nih.gov/pubmed/28423317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.068 |
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