Unraveling amino acid residues critical for allosteric potentiation of (α4)3(β2)2-type nicotinic acetylcholine receptor responses

Neuronal nicotinic acetylcholine receptors (nAChRs) are promising drug targets to manage several neurological disorders and nicotine addiction. Growing evidence indicates that positive allosteric modulators of nAChRs improve pharmacological specificity by binding to unique sites present only in a su...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Wang, Ze-Jun, Deba, Farah, Mohamed, Tasnim S., Chiara, David C., Ramos, Kara, Hamouda, Ayman K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473250/
https://ncbi.nlm.nih.gov/pubmed/28446611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771246
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