G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms

G protein-coupled receptor 30 (GPR30), also called G protein-coupled estrogen receptor 1 (GPER1), is thought to play important roles in breast cancer and cardiometabolic regulation, but many questions remain about ligand activation, effector coupling, and subcellular localization. We showed recently...

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Publicat a:J Biol Chem
Autors principals: Gonzalez de Valdivia, Ernesto, Broselid, Stefan, Kahn, Robin, Olde, Björn, Leeb-Lundberg, L. M. Fredrik
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473245/
https://ncbi.nlm.nih.gov/pubmed/28450397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.765875
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