G protein-coupled Receptor 30 (GPR30) Forms a Plasma Membrane Complex with Membrane-associated Guanylate Kinases (MAGUKs) and Protein Kinase A-anchoring Protein 5 (AKAP5) That Constitutively Inhibits cAMP Production

GPR30, or G protein-coupled estrogen receptor, is a G protein-coupled receptor reported to bind 17β-estradiol (E(2)), couple to the G proteins G(s) and G(i/o), and mediate non-genomic estrogenic responses. However, controversies exist regarding the receptor pharmacological profile, effector coupling...

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Detalhes bibliográficos
Main Authors: Broselid, Stefan, Berg, Kelly A., Chavera, Teresa A., Kahn, Robin, Clarke, William P., Olde, Björn, Leeb-Lundberg, L. M. Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139225/
https://ncbi.nlm.nih.gov/pubmed/24962572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.566893
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