Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression

Long-term treatment with ceftriaxone attenuates the reinstatement of cocaine seeking while increasing the function of the glutamate transporter 1 (GLT-1) and system xC- (Sxc) in the nucleus accumbens core (NAc). Sxc contributes the majority of nonsynaptic extracellular glutamate in the NAc, while GL...

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Pubblicato in:J Neurosci
Autori principali: LaCrosse, Amber L., O'Donovan, Sinead M., Sepulveda-Orengo, Marian T., McCullumsmith, Robert E., Reissner, Kathryn J., Schwendt, Marek, Knackstedt, Lori A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473201/
https://ncbi.nlm.nih.gov/pubmed/28495973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3717-16.2017
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