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Context matters: Contribution of specific DNA adducts to the genotoxic properties of the tobacco specific nitrosamine NNK
The tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human carcinogen by the International Agency for Cancer Research. NNK is bioactivated upon cytochrome P450 catalyzed hydroxylat...
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| Published in: | Chem Res Toxicol |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473167/ https://ncbi.nlm.nih.gov/pubmed/28092943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00386 |
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