AcrAB Efflux Pump Plays a Role in Decreased Susceptibility to Tigecycline in Morganella morganii

Transposon mutagenesis of a clinical isolate of Morganella morganii, G1492 (tigecycline MIC of 4 μg/ml), yielded two insertion knockout mutants for which tigecycline MICs were 0.03 μg/ml. Transposon insertions mapped to acrA, which is constitutively overexpressed in G1492, suggesting a role of the A...

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Bibliographic Details
Main Authors: Ruzin, Alexey, Keeney, David, Bradford, Patricia A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC547285/
https://ncbi.nlm.nih.gov/pubmed/15673770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.791-793.2005
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