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Preexisting domain motions underlie protonation-dependent structural transitions of the Ca(2+)-ATPase
We have performed microsecond molecular dynamics (MD) simulations to determine the mechanism for protonation-dependent structural transitions of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA). Release of two H(+) from the transport sites activates SERCA by inducing a structural transition between...
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| Yayımlandı: | Phys Chem Chem Phys |
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| Asıl Yazarlar: | , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5472844/ https://ncbi.nlm.nih.gov/pubmed/28374038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cp00243b |
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