LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

Genetically engineered pigs are a promising source for islet cell transplantation in type 1 diabetes, but the strong human anti-pig immune response prevents its successful clinical application. Here we studied the efficacy of neonatal porcine islet-like cell clusters (NPICCs) overexpressing LEA29Y,...

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Publicado no:Sci Rep
Main Authors: Buerck, L. Wolf-van, Schuster, M., Oduncu, F. S., Baehr, A., Mayr, T., Guethoff, S., Abicht, J., Reichart, B., Klymiuk, N., Wolf, E., Seissler, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472587/
https://ncbi.nlm.nih.gov/pubmed/28620237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03913-4
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