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Concomitant disruption of CD4 and CD8 genes facilitates the development of double negative αβ TCR(+) peripheral T cells that respond robustly to staphylococcal superantigen.

Mature peripheral double negative (DN) T cells expressing αβ TCR but lacking CD4/CD8 co-receptors play protective as well as pathogenic roles. To better understand their development and functioning in vivo, we concomitantly inactivated CD4 and CD8 genes in mice with intact MHC class I and class II m...

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Publicat a:J Immunol
Autors principals: Chowdhary, Vaidehi R., Krogman, Ashton, Tilahun, Ashenafi Y., Alexander, Mariam P., David, Chella S., Rajagopalan, Govindarajan
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471834/
https://ncbi.nlm.nih.gov/pubmed/28468970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601991
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