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Concomitant disruption of CD4 and CD8 genes facilitates the development of double negative αβ TCR(+) peripheral T cells that respond robustly to staphylococcal superantigen.
Mature peripheral double negative (DN) T cells expressing αβ TCR but lacking CD4/CD8 co-receptors play protective as well as pathogenic roles. To better understand their development and functioning in vivo, we concomitantly inactivated CD4 and CD8 genes in mice with intact MHC class I and class II m...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5471834/ https://ncbi.nlm.nih.gov/pubmed/28468970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601991 |
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