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Mouse models of Down syndrome: gene content and consequences
Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), is challenging to model in mice. Not only is it a contiguous gene syndrome spanning 35 Mb of the long arm of Hsa21, but orthologs of Hsa21 genes map to segments of three mouse chromosomes, Mmu16, Mmu17 and Mmu10. The Ts65Dn was the first vi...
Gespeichert in:
| Veröffentlicht in: | Mamm Genome |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5471624/ https://ncbi.nlm.nih.gov/pubmed/27538963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-016-9661-8 |
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