Human IL-6R(hi)TIGIT(−) CD4(+) CD127(low)CD25(+) T cells display potent in vitro suppressive capacity and a distinct Th17 profile

To date many clinical studies aim to increase the number and/or fitness of CD4(+) CD127(low)CD25(+) regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the hig...

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Publicat a:Clin Immunol
Autors principals: Ferreira, Ricardo C., Rainbow, Daniel B., Rubio García, Arcadio, Pekalski, Marcin L., Porter, Linsey, Oliveira, João J., Waldron-Lynch, Frank, Wicker, Linda S., Todd, John A.
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471606/
https://ncbi.nlm.nih.gov/pubmed/28284938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2017.03.002
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