Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein.

Expression of P-glycoprotein, encoded by the human MDR1 gene, results in cross-resistance to many lipophilic cytotoxic drugs (multidrug resistance). P-glycoprotein is believed to function as an energy-dependent efflux pump that is responsible for decreased drug accumulation in multidrug-resistant ce...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Safa, A R, Stern, R K, Choi, K, Agresti, M, Tamai, I, Mehta, N D, Roninson, I B
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1990
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC54716/
https://ncbi.nlm.nih.gov/pubmed/1976255
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