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Identification and Characterization of the Binding Sites of P-Glycoprotein for Multidrug Resistance-Related Drugs and Modulators

A major problem in cancer treatment is the development of resistance to multiple chemotherapeutic agents in tumor cells. A major mechanism of this multidrug resistance (MDR) is overexpression of the MDR1 product P-glycoprotein, known to bind to and transport a wide variety of agents. This review con...

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Bibliografiske detaljer
Udgivet i:Curr Med Chem Anticancer Agents
Hovedforfatter: Safa, Ahmad R.
Format: Artigo
Sprog:Inglês
Udgivet: 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447203/
https://ncbi.nlm.nih.gov/pubmed/14754408
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