Dendritic cells, engineered to overexpress 25-hydroxyvitamin D 1α-hydroxylase and pulsed with a myelin antigen, provide myelin-specific suppression of ongoing experimental allergic encephalomyelitis

Multiple sclerosis (MS) is caused by immune-mediated damage of myelin sheath. Current therapies aim to block such immune responses. However, this blocking is not sufficiently specific and hence compromises immunity, leading to severe side effects. In addition, blocking medications usually provide tr...

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Detalles Bibliográficos
Publicado en:FASEB J
Autores principales: Li, Chih-Huang, Zhang, Jintao, Baylink, David J., Wang, Xiaohua, Goparaju, Naga Bharani, Xu, Yi, Wasnik, Samiksha, Cheng, Yanmei, Berumen, Edmundo Carreon, Qin, Xuezhong, Lau, Kin-Hing William, Tang, Xiaolei
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471518/
https://ncbi.nlm.nih.gov/pubmed/28363955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601243R
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