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Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules
In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of NMR studies revealed that Az associates with an ATPase doma...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5471252/ https://ncbi.nlm.nih.gov/pubmed/28615625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03814-6 |
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