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Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules
In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of NMR studies revealed that Az associates with an ATPase doma...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5471252/ https://ncbi.nlm.nih.gov/pubmed/28615625 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03814-6 |
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