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Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of NMR studies revealed that Az associates with an ATPase doma...

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Vydáno v:Sci Rep
Hlavní autoři: Park, Seong-Hyun, Kim, Won-Je, Li, Hui, Seo, Wonil, Park, Sang-Hyun, Kim, Hwan, Shin, Sang Chul, Zuiderweg, Erik R. P., Kim, Eunice EunKyeong, Sim, Taebo, Kim, Nak-Kyoon, Shin, Injae
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471252/
https://ncbi.nlm.nih.gov/pubmed/28615625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03814-6
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