Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules

In this study we examined the anti-leukemia activity of a small molecule inhibitor of Hsp70 proteins, apoptozole (Az), and hybrids in which it is linked to an inhibitor of either Hsp90 (geldanamycin) or Abl kinase (imatinib). The results of NMR studies revealed that Az associates with an ATPase doma...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Park, Seong-Hyun, Kim, Won-Je, Li, Hui, Seo, Wonil, Park, Sang-Hyun, Kim, Hwan, Shin, Sang Chul, Zuiderweg, Erik R. P., Kim, Eunice EunKyeong, Sim, Taebo, Kim, Nak-Kyoon, Shin, Injae
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471252/
https://ncbi.nlm.nih.gov/pubmed/28615625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03814-6
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