Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation

Epigenetic regulation of differentiation-related genes is poorly understood. We previously reported that transcription factors GATA6 and Sp1 interact with and activate the rat proximal 358-bp promoter/enhancer (p358P/E) of lung alveolar epithelial type I (AT1) cell-specific gene aquaporin-5 (Aqp5)....

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Udgivet i:Sci Rep
Main Authors: Flodby, Per, Li, Changgong, Liu, Yixin, Wang, Hongjun, Rieger, Megan E., Minoo, Parviz, Crandall, Edward D., Ann, David K., Borok, Zea, Zhou, Beiyun
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471216/
https://ncbi.nlm.nih.gov/pubmed/28615712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03152-7
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