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Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse

ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the molecular pathogenesis of E/R-positive ALL, whereby E/R rearrangement is followed by a series of secondary mutations that trigger overt leukemia...

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Foilsithe in:Oncotarget
Main Authors: Sun, Congcong, Chang, Lixian, Zhu, Xiaofan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471068/
https://ncbi.nlm.nih.gov/pubmed/28418909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16367
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