Clinical framework for next generation sequencing based analysis of treatment predictive mutations and multiplexed gene fusion detection in non-small cell lung cancer

Precision medicine requires accurate multi-gene clinical diagnostics. We describe the implementation of an Illumina TruSight Tumor (TST) clinical NGS diagnostic framework and parallel validation of a NanoString RNA-based ALK, RET, and ROS1 gene fusion assay for combined analysis of treatment predict...

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Vydáno v:Oncotarget
Hlavní autoři: Lindquist, Kajsa Ericson, Karlsson, Anna, Levéen, Per, Brunnström, Hans, Reuterswärd, Christel, Holm, Karolina, Jönsson, Mats, Annersten, Karin, Rosengren, Frida, Jirström, Karin, Kosieradzki, Jaroslaw, Ek, Lars, Borg, Åke, Planck, Maria, Jönsson, Göran, Staaf, Johan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471012/
https://ncbi.nlm.nih.gov/pubmed/28415793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16276
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