NELL-1 induces Sca-1(+) mesenchymal progenitor cell expansion in models of bone maintenance and repair

NELL-1 is a secreted, osteogenic protein first discovered to control ossification of the cranial skeleton. Recently, NELL-1 has been implicated in bone maintenance. However, the cellular determinants of NELL-1’s bone-forming effects are still unknown. Here, recombinant human NELL-1 (rhNELL-1) implan...

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Veröffentlicht in:JCI Insight
Hauptverfasser: James, Aaron W., Shen, Jia, Tsuei, Rebecca, Nguyen, Alan, Khadarian, Kevork, Meyers, Carolyn A., Pan, Hsin Chuan, Li, Weiming, Kwak, Jin H., Asatrian, Greg, Culiat, Cymbeline T., Lee, Min, Ting, Kang, Zhang, Xinli, Soo, Chia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470886/
https://ncbi.nlm.nih.gov/pubmed/28614787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92573
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