A Functional Virulence Complex Composed of Gingipains, Adhesins, and Lipopolysaccharide Shows High Affinity to Host Cells and Matrix Proteins and Escapes Recognition by Host Immune Systems

Arg-gingipain (Rgp) and Lys-gingipain (Kgp) are Porphyromonas gingivalis cysteine proteinases implicated as major virulence factors in pathologies of periodontitis. We purified a 660-kDa cell-associated gingipain complex existing as a homodimer of two catalytically active monomers which comprises th...

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Bibliographische Detailangaben
Veröffentlicht in:Infect Immun
Hauptverfasser: Takii, Ryosuke, Kadowaki, Tomoko, Baba, Atsuyo, Tsukuba, Takayuki, Yamamoto, Kenji
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2005
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC547079/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15664930/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.73.2.883-893.2005
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