Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress

BACKGROUND: Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We invest...

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Detalhes bibliográficos
Publicado no:PLoS Negl Trop Dis
Main Authors: Deep, Deepak Kumar, Singh, Ruchi, Bhandari, Vasundhra, Verma, Aditya, Sharma, Vanila, Wajid, Saima, Sundar, Shyam, Ramesh, V., Dujardin, Jean Claude, Salotra, Poonam
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470736/
https://ncbi.nlm.nih.gov/pubmed/28575060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005641
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