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Docosahexaenoic acid causes rapid pulmonary arterial relaxation via KCa channel-mediated hyperpolarisation in pulmonary hypertension

Cardioprotective benefits of ω-3 fatty acids such as docosahexaenoic acid (DHA) are well established, but the regulatory effect of DHA on vascular tone and pressure in pulmonary hypertension is largely unknown. As DHA is a potent regulator of K(+) channels, we hypothesised that DHA modulates the mem...

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Detalhes bibliográficos
Publicado no:Eur Respir J
Main Authors: Nagaraj, Chandran, Tang, Bi, Nagy, Bence M., Papp, Rita, Jain, Pritesh P., Marsh, Leigh M., Meredith, Andrea L., Ghanim, Bahil, Klepetko, Walter, Kwapiszewska, Grazyna, Weir, E. Kenneth, Olschewski, Horst, Olschewski, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470640/
https://ncbi.nlm.nih.gov/pubmed/27540020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.01814-2015
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