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The genetics of myelodysplastic syndrome: from clonal hematopoiesis to secondary leukemia

Myelodysplastic syndrome (MDS) is a clonal disease that arises from the expansion of mutated hematopoietic stem cells. In a spectrum of myeloid disorders ranging from clonal hematopoiesis of indeterminate potential (CHIP) to secondary acute myeloid leukemia (sAML), MDS is distinguished by the presen...

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Bibliographic Details
Published in:Nat Rev Cancer
Main Authors: Sperling, Adam S., Gibson, Christopher J., Ebert, Benjamin L.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470392/
https://ncbi.nlm.nih.gov/pubmed/27834397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2016.112
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