PppA, a Surface-Exposed Protein of Streptococcus pneumoniae, Elicits Cross-Reactive Antibodies That Reduce Colonization in a Murine Intranasal Immunization and Challenge Model

The multivalent pneumococcal conjugate vaccine is effective against both systemic disease and otitis media caused by serotypes contained in the vaccine. However, serotypes not covered by the present conjugate vaccine may still cause pneumococcal disease. To address these serotypes, and the remaining...

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Bibliographic Details
Main Authors: Green, Bruce A., Zhang, Ying, Masi, Amy W., Barniak, Vicki, Wetherell, Michael, Smith, Robert P., Reddy, Molakala S., Zhu, Duzhang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC547003/
https://ncbi.nlm.nih.gov/pubmed/15664941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.2.981-989.2005
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