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Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host
Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks impeding the wider use. Therefore, improvement in telome...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5469769/ https://ncbi.nlm.nih.gov/pubmed/28611443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03308-5 |
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