SerpinB3 Promotes Pro-fibrogenic Responses in Activated Hepatic Stellate Cells

SerpinB3 is a hypoxia- and hypoxia-inducible factor-2α-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been reported to correlate with the extent of liver fi...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Novo, Erica, Villano, Gianmarco, Turato, Cristian, Cannito, Stefania, Paternostro, Claudia, Busletta, Chiara, Biasiolo, Alessandra, Quarta, Santina, Morello, Elisabetta, Bocca, Claudia, Miglietta, Antonella, David, Ezio, Sutti, Salvatore, Plebani, Mario, Albano, Emanuele, Parola, Maurizio, Pontisso, Patrizia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469760/
https://ncbi.nlm.nih.gov/pubmed/28611447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03744-3
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