Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient Mice

Multiple pathogenic Gram-negative bacteria produce the cytolethal distending toxin (CDT) with activity of DNase I; CDT can induce DNA double strand breaks (DSBs), G2/M cell cycle arrest and apoptosis in cultured mammalian cells. However, the link of CDT to in vivo tumorigenesis is not fully understo...

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Vydáno v:Cell Microbiol
Hlavní autoři: Ge, Zhongming, Feng, Yan, Ge, Lili, Parry, Nicole, Muthupalani, Suresh, Fox, James G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469717/
https://ncbi.nlm.nih.gov/pubmed/28111881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12728
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