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JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: inspired by functional and structural genomics
Abnormal activation of the γc cytokine JAK/STAT signaling pathway assessed by STAT3 or STAT5b phosphorylation was present in a proportion of many T-cell malignancies. Activating mutations of STAT3/STAT5b and JAK1/3 were present in some but not in all cases with constitutive signaling pathway activat...
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| Publicado en: | Mol Cell Endocrinol |
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| Autor principal: | |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5469693/ https://ncbi.nlm.nih.gov/pubmed/28214593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2017.02.019 |
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