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JAK/STAT pathway directed therapy of T-cell leukemia/lymphoma: inspired by functional and structural genomics

Abnormal activation of the γc cytokine JAK/STAT signaling pathway assessed by STAT3 or STAT5b phosphorylation was present in a proportion of many T-cell malignancies. Activating mutations of STAT3/STAT5b and JAK1/3 were present in some but not in all cases with constitutive signaling pathway activat...

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Bibliografski detalji
Izdano u:Mol Cell Endocrinol
Glavni autor: Waldmann, Thomas A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469693/
https://ncbi.nlm.nih.gov/pubmed/28214593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2017.02.019
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