Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent relaxation and energetic deficits that characterize...

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Bibliographic Details
Published in:eLife
Main Authors: Alamo, Lorenzo, Ware, James S, Pinto, Antonio, Gillilan, Richard E, Seidman, Jonathan G, Seidman, Christine E, Padrón, Raúl
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Human Biology and Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469618/
https://ncbi.nlm.nih.gov/pubmed/28606303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24634
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