Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent relaxation and energetic deficits that characterize...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Alamo, Lorenzo, Ware, James S, Pinto, Antonio, Gillilan, Richard E, Seidman, Jonathan G, Seidman, Christine E, Padrón, Raúl
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2017
Aiheet:
Human Biology and Medicine
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469618/
https://ncbi.nlm.nih.gov/pubmed/28606303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24634
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